What is a primary reason for avoiding blood collection from a patient with a recent mastectomy?

Avoiding blood collection from a patient with a recent mastectomy is primarily linked to the risk of lymphatic complications. When a mastectomy is performed, especially if lymph nodes are also removed, the lymphatic drainage in that area is altered. This may lead to the development of lymphedema, where lymph fluid accumulates in the tissues, potentially causing swelling and discomfort. Collecting blood from the affected arm or side can exacerbate this condition, leading to increased risks for infections and further complications.

The other reasons, such as the development of allergies, increased risk of hematomas, and unnecessary pain, while valid concerns in different contexts, do not specifically address the primary issue resulting from the surgical removal of breast tissue and associated lymph nodes. Lymphatic complications are the foremost concern, making this the most critical factor when determining the appropriateness of venipuncture in affected patients.