What does the term "drying artifact" refer to in histology?

The term "drying artifact" in histology specifically refers to alterations in the appearance of a specimen caused by the evaporation of moisture as it is processed or prepared for microscopic examination. When tissues are dehydrated too rapidly or inadequately moistened, it can lead to changes in structure, such as the formation of cracks or irregularities, which do not accurately represent the true morphology of the tissue. This can affect the interpretation of the histological features, leading to potential diagnostic errors.

Understanding drying artifacts is crucial for laboratory professionals, as it emphasizes the importance of proper specimen handling and processing techniques to maintain the integrity of biological samples. Recognizing how drying can influence the overall quality of the specimen helps ensure accurate analysis and reliable results in histopathology.