True or False: Fixating the specimen does not change the color of the tissue.

Fixation is a crucial step in preparing tissue specimens for histological examination, and it primarily serves to preserve the structure and composition of the tissue. During fixation, various chemical agents are used, such as formaldehyde or glutaraldehyde. These substances interact with the proteins in the tissue, leading to a number of changes including potential alterations in color.

The process often involves cross-linking proteins, which can darken or change the overall appearance of the tissue. Therefore, it is accurate to state that fixation does indeed change the color of the tissue in many circumstances. This coloration can be affected by the type of fixative used, the tissue composition, and the duration of fixation, illustrating why it's essential to acknowledge that fixation typically impacts the color. Hence, the statement that fixating the specimen does not change the color of the tissue is false.