Is it true that if the nucleus is not acidic, it does not attract methylene blue, which is basic?

The idea that the nucleus must be acidic to attract methylene blue is not accurate. Methylene blue is a basic dye that binds to the negatively charged components of cells, such as nucleic acids (DNA and RNA), which are located in the nucleus. The binding occurs because of the positive charge of the methylene blue molecules, allowing them to interact with the negatively charged phosphate backbone of nucleic acids.

Therefore, the attraction of methylene blue to the nucleus is primarily related to the presence of nucleic acids rather than the acidity of the nucleus. An acidic environment could influence the overall cellular environment, but it is not a prerequisite for the binding of methylene blue. The cellular components that interact with the dye are influenced more by their biochemical properties rather than the pH level alone.

Overall, the fact that methylene blue is basic and attracted to nucleic acids means that the statement regarding the necessity of the nucleus being acidic for attraction is not true.